Clinical Trial

The READI-SET-GO study (NCT05915377) is a multi-site, stepped-wedge implementation trial led by Penn State University, aiming to integrate daily delirium screening into routine care for hospitalized older adults. Conducted across six general medicine and surgery units at three hospitals in Pennsylvania and Massachusetts, the study evaluates the impact of daily nurse-administered delirium screening using the Ultra-Brief Confusion Assessment Method (UB-CAM).

 

Timeline

  • Study Start: April 3, 2024

  • Primary Completion: July 2027

  • Study Completion: December 2027

This study is actively recruiting participants and aims to enhance delirium detection and management, ultimately improving outcomes for hospitalized older adults.

For more detailed information, you can access the full study details here.

Study Design

  • Implementation Strategy: The UB-CAM screening will be introduced sequentially to each unit every six months over a 42-month period.

  • Participants: Approximately 1,050 hospitalized adults aged 70 and older, expected to stay at least three days, will be enrolled. Informed consent will be obtained for a subset of 1,050 patients, who will undergo up to three reference standard delirium assessments (RSDAs) and participate in follow-up interviews. Additionally, 20,000 patients aged 70 and older will be included in an administrative sample to assess broader outcomes.

  • Primary Outcomes:

    1. Fidelity and Accuracy: Assessing the percentage of eligible days with completed nurse delirium screens and the agreement between nurse-administered UB-CAM and RSDAs.

    2. Patient and Care Partner Outcomes: Evaluating Healthy Days at Home (HDAH), delirium-related distress, and perceptions of communication and collaboration through follow-up interviews.

    3. Delirium Complications and Management: Monitoring rates of falls, pressure injuries, aspiration pneumonia, and the use of physical restraints or antipsychotic medications.